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How does Scout calculate or show VAF/AF? Probably incorrect AF is show on a case

See original GitHub issue

The variant https://scout.scilifelab.se/cust087/F0041488-2/cancer/31241819ff9fff9273bc6c4e34aa0ccb?cancer=yes shows an AF of 0.4889:

image

Is VAF recalculated on Scout? When I look at the case cleanasp on Hasta, VAF is set at 0.375

X 100611164 . C T 284 PASS SAMPLE=cleanasp;TYPE=SNV;DP=703;VD=264;AF=0.3755

Does Scout recalculate VAFs? Where does 0.4889 come from? Or am I looking at wrong case?

Issue Analytics

  • State:open
  • Created 2 years ago
  • Comments:12 (10 by maintainers)

github_iconTop GitHub Comments

1reaction
northwestwitchcommented, Oct 13, 2021

Tested installing Scout with an up-to-date version of cyvcf2 (0.30.11). The problem persists

1reaction
northwestwitchcommented, Oct 13, 2021

@hassanfa never mind, I got it!

Read more comments on GitHub >

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