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dotnet run does not work on osx using netXXX TargetFramework

See original GitHub issue

On Mac–> 10.13.3

Steps to reproduce

dotnet new console -o myApp change myApp.csproj to be

<Project Sdk="Microsoft.NET.Sdk">
  <PropertyGroup>
    <OutputType>Exe</OutputType>
    <TargetFramework>net451</TargetFramework>
  </PropertyGroup>
</Project>

dotnet run

Expected behavior

You see Hello World printed out

Actual behavior

System.ComponentModel.Win32Exception (0x80004005): Permission denied
   at Interop.Sys.ForkAndExecProcess(String filename, String[] argv, String[] envp, String cwd, Boolean redirectStdin, Boolean redirectStdout, Boolean redirectStderr, Int32& lpChildPid, Int32& stdinFd, Int32& stdoutFd, Int32& stderrFd)
   at System.Diagnostics.Process.StartCore(ProcessStartInfo startInfo)
   at System.Diagnostics.Process.Start()
   at Microsoft.DotNet.Cli.Utils.Command.Execute()
   at Microsoft.DotNet.Tools.Run.RunCommand.Start()
   at Microsoft.DotNet.Tools.Run.RunCommand.Run(String[] args)
   at Microsoft.DotNet.Cli.Program.ProcessArgs(String[] args, ITelemetry telemetryClient)
   at Microsoft.DotNet.Cli.Program.Main(String[] args)

Environment data

dotnet --info output:

.NET Command Line Tools (2.1.4)

Product Information:
 Version:            2.1.4
 Commit SHA-1 hash:  5e8add2190

Runtime Environment:
 OS Name:     Mac OS X
 OS Version:  10.13
 OS Platform: Darwin
 RID:         osx.10.12-x64
 Base Path:   /usr/local/share/dotnet/sdk/2.1.4/

Microsoft .NET Core Shared Framework Host

  Version  : 2.0.5
  Build    : 17373eb129b3b05aa18ece963f8795d65ef8ea54