Can't debug WPF project after upgrade from .NET5 to .NET6

• .NET Core Version: 6.0.100
• Windows version: Windows 11 Pro
• IDE: Visual Studio 2022 and Rider
• Does the bug reproduce also in WPF for .NET Framework 4.8?: Have not tried but it’s working in .NET5.

Problem description: Changed from .NET5 to .NET6 by changing TargetFramework in .csproj. I now get the error message in VS2022: “Unable to attach to CoreCLR. Operation not supported. Unknown error: 0x80004005.” Publish and “Start without debugging” works, both in VS and Rider.

What I have tried:

1. I have uppdated all nugets
2. Re-installed Visual Studio 2022
3. Re-installed .Net6
4. Clean and rebuild.

Actual behavior: Visual Studio error message:

Rider error message: C:\Users\user\AppData\Local\JetBrains\Toolbox\apps\Rider\ch-0\212.5284.64\lib\ReSharperHost\JetBrains.Debugger.Worker64c.exe --mode=client --frontend-port=53344 --plugins=C:\Users\user\AppData\Local\JetBrains\Toolbox\apps\Rider\ch-0\212.5284.64\plugins\rider-unity\dotnetDebuggerWorker One or more errors have occurred.

csproj

<Project Sdk="Microsoft.NET.Sdk">

  <PropertyGroup>
    <OutputType>WinExe</OutputType>
    <TargetFramework>net6.0-windows</TargetFramework>
    <UseWPF>true</UseWPF>
    <RuntimeIdentifier>win10-x64</RuntimeIdentifier>
    <PublishSingleFile>true</PublishSingleFile>
    <ApplicationIcon>Business_Target.ico</ApplicationIcon>
    <UseWindowsForms>False</UseWindowsForms>
    <ImplicitUsings>disable</ImplicitUsings>
	<SelfContained>true</SelfContained>
	<IncludeAllContentForSelfExtract>true</IncludeAllContentForSelfExtract>
  </PropertyGroup>

  <ItemGroup>
    <ProjectReference Include="..\ProjectOrganizer.Dto\ProjectOrganizer.Dto.csproj" />
    <ProjectReference Include="..\ProjectOrganizer.Shared\ProjectOrganizer.Shared.csproj">
    </ProjectReference>
  </ItemGroup>

  <ItemGroup>
    <PackageReference Include="AsyncAwaitBestPractices" Version="6.0.2" />
    <PackageReference Include="Autofac" Version="6.3.0" />
    <PackageReference Include="Autofac.Extensions.DependencyInjection" Version="7.2.0" />
    <PackageReference Include="DevExpress.Images" Version="21.2.3" />
    <PackageReference Include="DevExpress.Wpf" Version="21.2.3" />
    <PackageReference Include="DevExpress.Wpf.Themes.Office2019Black" Version="21.2.3" />
    <PackageReference Include="Microsoft.EntityFrameworkCore" Version="6.0.0" />
    <PackageReference Include="Microsoft.Extensions.Http" Version="6.0.0" />
    <PackageReference Include="Microsoft.Extensions.Http.Polly" Version="6.0.0" />
    <PackageReference Include="Mono.Cecil" Version="0.11.4" />
    <PackageReference Include="Polly.Extensions.Http" Version="3.0.0" />
    <PackageReference Include="Prism.Core" Version="8.1.97" />
  </ItemGroup>

</Project>

[Reelix]

If your project is set to PublishSingleFile, this issue is being tracked over at https://github.com/dotnet/runtime/issues/45382

[EtherGhost]

@Reelix Wow, that helped! Thank’s a lot! I did not think that PublishSingleFile would apply to debug at all, only when publish. Thank’s! @lindexi Thank you for your help too!