ImportError: libcrypto.so.1.0.0

The code in Download binaries, models, and test data the of the DV quick start guide ran successfully. However, running make_examples using the quickstart-testdata failed with the following error:

Traceback (most recent call last):
attila-ThinkS:~/tools/deepvariant$ python bin/make_examples.zip \
>   --mode calling   \
>   --ref "${REF}"   \
>   --reads "${BAM}" \
>   --regions "chr20:10,000,000-10,010,000" \
>   --examples "${OUTPUT_DIR}/examples.tfrecord.gz"
  File "/tmp/Bazel.runfiles_pbJgd2/runfiles/genomics/deepvariant/make_examples.py", line 45, in <module>
    from deepvariant import variant_caller
  File "/tmp/Bazel.runfiles_pbJgd2/runfiles/genomics/deepvariant/variant_caller.py", line 50, in <module>
    from deepvariant.python import variant_calling
ImportError: libcrypto.so.1.0.0: cannot open shared object file: No such file or directory

[pgrosu]

Hi Mark (@depristo),

There is a theme of elegance with the current implementation that I tend to appreciate, though I agree that streamlining it for support/growth is rich with opportunities to explore. Let me know if you would like to work on it together - or just bounce off ideas - as some could be low-hanging fruit with simple remedies.

Best, Paul

[depristo]

@pgrosu Thanks Paul, we appreciate the close eye you’ve given to the codebase. Unfortunately managing all of the dependencies is challenging, and we aren’t super happy with how complex the build/run prereqs scripts are. And we agree with you that there’s a lot of opportunity to explore extensions, simplifications, and optimizations of DeepVariant.