ProtocolError while using pip (OSError 22 Invalid argument)

Description

If I try to install a package via pip or try to upgrade pip (python -m pip install --upgrade pip) it fails (see output below).

With Python 3.6 I do not have any problems. I also tried Python 3.8, which has the same behavior than Python 3.9 (32 and 64-bit version).

Deactivating IPV6 did not work. Calling pip install --upgrade pip -i http://pypi.douban.com/simple --trusted-host pypi.douban.com as written here (https://github.com/pypa/pip/issues/9216#issuecomment-738738453) also works for me but is not a solution.

Expected behavior

pip is updated.

pip version

21.2.3

Python version

3.9.7

OS

Windows 10, 64-bit

How to Reproduce

1. open a terminal
2. call python -m pip install --upgrade pip

Output

WARNING: Retrying (Retry(total=4, connect=None, read=None, redirect=None, status=None)) after connection broken by 'ProtocolError('Connection aborted.', OSError(22, 'Invalid argument'))': /simple/pip/
WARNING: Retrying (Retry(total=3, connect=None, read=None, redirect=None, status=None)) after connection broken by 'ProtocolError('Connection aborted.', OSError(22, 'Invalid argument'))': /simple/pip/
WARNING: Retrying (Retry(total=2, connect=None, read=None, redirect=None, status=None)) after connection broken by 'ProtocolError('Connection aborted.', OSError(22, 'Invalid argument'))': /simple/pip/
WARNING: Retrying (Retry(total=1, connect=None, read=None, redirect=None, status=None)) after connection broken by 'ProtocolError('Connection aborted.', OSError(22, 'Invalid argument'))': /simple/pip/
WARNING: Retrying (Retry(total=0, connect=None, read=None, redirect=None, status=None)) after connection broken by 'ProtocolError('Connection aborted.', OSError(22, 'Invalid argument'))': /simple/pip/

### Code of Conduct

- [X] I agree to follow the [PSF Code of Conduct](https://www.python.org/psf/conduct/).

[pfmoore]

That \u202a appears to be Left-To-Right Embedding. I suspect you have C:\Users\xxx\Desktop\sslkeylog.log in a config file somewhere but it’s got that (invisible) extra character included by accident somehow.

[Kiolali]

Well, you should not be able to run pip search, since the XMLRPC was disabled on PyPI.org.

I know, but the error message was quite helpful (in contrast to the command pip install x). I could resolve my problem by deleting the environment variable SSLKEYLOGFILE. I really have no idea how this variable was set. My other laptop doesn’t have that variable.